Synthesis of 2-Amino-3,5-dicarbonitrile-6-thiopyridines Using Silica-bonded N-Propyldiethylenetriamine as a Heterogeneous Solid Base Catalyst

Niknam, Khodabakhsh; Hosseini, Alireza

doi:10.22036/org.chem..2017.41100

Synthesis of 2-Amino-3,5-dicarbonitrile-6-thiopyridines Using Silica-bonded N-Propyldiethylenetriamine as a Heterogeneous Solid Base Catalyst

Document Type : Full Paper

Authors

Khodabakhsh Niknam

Alireza Hosseini

Persian Gulf University

10.22036/org.chem..2017.41100

Abstract

Silica-bonded N-propyldiethylenetriamine (7) is employed as a recyclable heterogeneous solid base catalyst for the synthesis of 2-amino-3,5-dicarbonitrile-6-thiopyridines through pseudo four-component condensation reaction between aromatic aldehydes, malononitrile, and 2-amino-thiophenol in refluxing ethanol. Silica-bonded N-propyldiethylenetriamine showed much the same efficiency when used in consecutive reaction runs.

Keywords

2-Amino-3

5-dicarbonitrile-6-thiopyridines

Heterogeneous catalysts

Solid bases

Synthesis

Multi-component reactions