Synthesis of Pyridopyrimidine-Indole Hybrids Using γ-Fe2O3@HAp@PBABMD@Cu as Efficient Magnetic Nanocatalyst

Document Type : Full Paper

Authors

1 Department of Chemistry, Faculty of Sciences, University of Guilan, P.O. Box 41335-1914, Rasht, Iran

2 Department of Chemistry, Faculty of Sciences, University of Guilan, P. O. Box: 41335-1914, Rasht, Iran

10.22036/org.chem.2022.316963.1268

Abstract

A novel and practical method for the synthesis of pyridopyrimidine-indole hybrids, using a three-component reaction of thiouracil or 6-amino-N,N-dimethyluracil, various aryl aldehydes and 3-cyanoacetyl indole in the presence of a green heterogeneous nano-catalyst γ-Fe2O3@HAp@PBABMD@Cu was developed. This protocol furnished the desired products in high yields (82-95%) and lower reaction times (18-40 min).

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