Bis (1(3-trimethoxysilylpropyl)-3-methyl-imidazolium) Nickel Tetrachloride Tethered to Colloidal Silica Nanoparticles as a Superior Catalyst for the Bis-thiazolidinones Preparation

Document Type : Full Paper


Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, P.O. Box 87317-51167, I. R. Iran


An easy and rapid method for the synthesis of bis-thiazolidinones has been presented by one-pot pseudo-five-component reaction of benzaldehydes, ethylenediamine, 2-mercaptoacetic acid with bis (1(3-trimethoxysilylpropyl)-3-methyl-imidazolium) nickel tetrachloride tethered to colloidal silica nanoparticles. Atom economy, low catalyst loading, reusable catalyst, applicability to a wide range of substrates and high yields of products are some of the important features of this protocol.