Catalyst-Free One-Pot Four-Component Synthesis of 3-(Imino)-pyrrolo[2,1-a]isoquinolines in Glycerol: Two Different Products through Two Different Purification Methods

Document Type : Full Paper


1 Department of Applied Chemistry, Shiraz Branch, Islamic Azad University, P.O. Box 71993-5, Shiraz, Iran

2 Chemistry Department, College of Sciences, Shiraz University, Shiraz, Iran


The one-pot four component synthesis of 3-(Imino)-2,3-dihydropyrrolo[2,1-a]isoquinoline-1,1(10bH)-dicarbonitrile derivatives via a catalyst-free reaction between aryl aldehydes, malononitrile, isoquinoline and isocyanides was successfully conducted in glycerol as a benign, nontoxic and biodegradable promoting reaction medium. The progress of the reaction with two different common purification methods were investigated. Moreover, synthesized products were examined as chemical sensors for the detection of a wide range of metal ions and it was successful for the detection of Co2+ ions.