Aluminum Oxide Nanoparticle as a Valuable Heterogeneous Nanocatalyst in the Synthesis of 2-Aminothiazole Scaffolds

Document Type : Full Paper


1 aLaboratory of Organic Compound Research, Department of Organic Chemistry, College of Chemistry and Biochemistry, University of Kashan, P.O. Box: 87317-51167, Kashan, I.R, Iran.

2 Research Affiliate, Department of Chemistry, University of Payame Noor, P.O. BOX 19395-4697, Tehran-IRAN


An efficient methodology for the preparation of 2-aminothiazoles is achieved by one-pot reaction of methylcarbonyls, thiourea and iodine in the presence of an aluminum oxide nanoparticle as an active nanocatalyst at 85 °C in DMSO solvent. Al2O3 nanoparticles have been prepared via co-precipitation method and their structures were confirmed using Fourier transform infrared radiation (FT-TR), X-ray diffraction (XRD), scanning electron microscopic (SEM), and energy-dispersive analysis of X-ray (EDAX) analyses. Advantages of this efficient synthetic approach include higher purity and excellent yield of products, easy isolation of products and convenient manipulation.