Nano Silica Melamine Trisulfonic Acid as an Efficient and Reusable Heterogeneous Catalyst for the Synthesis of 5-Substituted-1H-Tetrazoles

Document Type : Full Paper


Department of Chemistry, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran


A convenient method for the synthesis of 5-substituted-1H-tetrazoles from organic nitriles and sodium azide in the presence of nano silica melamine trisulfonic acid is reported. A series of aliphatic and aromatic nitriles were underwent a [3+2] cycloaddtion with sodium azide to afford tetrazoles in good to excellent yields and acceptable reaction times. The nano silica melamine trisulfonic acid is an efficient heterogeneous nanocatalyst with high catalytic performance. The nano silica melamine trisulfonic acid is readily prepared, environmentally friendly and reusable. The catalyst was characterized by Powder X-ray diffraction, energy-dispersive X-ray mapping and SEM techniques. The procedure was simple, cost effective that holds potential for further applications in organic syntheses and industrial requirements.