Four-component Cascade Reaction was Programmed and Catalyzed by B(OH)3.H2O as an Efficient and Green Catalytic System

Moosavi-Zare, Ahmad Reza; Afshar-Hezarkhani, Hadis; Khakizadeh, Vahid; Goudarziafshar, Hamid

doi:10.22036/org.chem.2018.122359.1133

Four-component Cascade Reaction was Programmed and Catalyzed by B(OH)3.H2O as an Efficient and Green Catalytic System

Document Type : Full Paper

Authors

Ahmad Reza Moosavi-Zare ¹

Hadis Afshar-Hezarkhani ²

Vahid Khakizadeh ³

Hamid Goudarziafshar ⁴

¹ Department of Chemistry, University of Sayyed Jamaleddin Asadabadi, Asadabad 6541835583, Iran

² Sayyed Jamaleddin Asadabadi University, Asadabad, 6541835583, I. R. Iran.

³ Khajeh Nasir Toosi University, Tehran, Iran

⁴ Sayyed Jamaleddin Asadabadi University, Asadabad, 6541835583, I. R. Iran

10.22036/org.chem.2018.122359.1133

Abstract

An aqueous solution of boric acid, as an efficient and green catalytic system, was efficiently utilized four-component cascade reaction of aryl aldehydes, dimedone, β-ketoesters and ammonium acetate to give hexahydroquinolines. By the reaction of boric acid with water, H+ was generated and efficiently catalyzed the reaction under mild and green condition. Also, optimization of the reaction condition was investigated using the response surface method {Central Composite Design (CCD)}.

Keywords

Boric acid

Hexahydroquinoline

Cascade reaction

Aqueous solution