Efficient Oxidative Dehydrogenation of Dihydropyrimidinones and Thiocyanation of Aromatic Compounds Using 1,1,2,2-Tetrahydroperoxy-1,2-diphenylethane as the Oxidant

Khosravi, Kaveh; Azizi, Amir; Naserifar, Shirin

doi:10.22036/org.chem.2018.133843.1152

Efficient Oxidative Dehydrogenation of Dihydropyrimidinones and Thiocyanation of Aromatic Compounds Using 1,1,2,2-Tetrahydroperoxy-1,2-diphenylethane as the Oxidant

Document Type : Full Paper

Authors

Kaveh Khosravi ¹

Amir Azizi ²

Shirin Naserifar ¹

¹ Faculty of Science, Department of Chemistry, Arak University, Arak 38156-8-8349, Iran.

² Faculty of Science, Department of Chemistry, Arak University, Arak 38156-8-8349, Iran

10.22036/org.chem.2018.133843.1152

Abstract

A new, efficient and mild approach for the oxidative dehydrogenation of dihydropyrimidinones and thiocyanation of aromatic compounds using 1,1,2,2-tetrahydroperoxy-1,2-diphenylethane (THPDPE) as a terminal oxidant was developed. Initially, various substrates bearing different electron-donating and electron-releasing functionalities were synthesized and next under the optimized reaction conditions the desired products were yielded after an easy work-up and the structures were characterized compared with those reported. All of the reactions proceeded in short reaction times and 1,1,2,2-tetrahydroperoxy-1,2-diphenylethane (THPDPE) proved its potential to yield the desired products in high yields.

Keywords

Dehydropirimidinones

Oxidative dehydrogenation

Thiocyanation

2-Tetrahydroperoxy-1

2-diphenylethane

Pyrimidinones