La(OTf)2-amine Grafted-GO as the First Multifunctional Catalyst for the One-pot Three-component Synthesis of α-Aminophosphonates

Sobhani, Sara; Zarifi, Farzaneh; Barani, Farshid; Skibsted, Jorgen

doi:10.22036/org.chem.2018.140499.1166

La(OTf)2-amine Grafted-GO as the First Multifunctional Catalyst for the One-pot Three-component Synthesis of α-Aminophosphonates

Document Type : Full Paper

Authors

Sara Sobhani ¹

Farzaneh Zarifi ¹

Farshid Barani ¹

Jorgen Skibsted ²

¹ Department of Chemistry, College of Sciences, University of Birjand, Birjand, Iran

² bDepartment of Chemistry and Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Langelandsgade 140, DK-8000 Aarhus C, Denmark

10.22036/org.chem.2018.140499.1166

Abstract

In this paper, the applicability of immobilized lanthanum (III) triflate on amine grafted graphene oxide [La(OTf)2-amine grafted-GO] as the first multifunctional catalyst is described for the efficient synthesis of α-aminophosphonates by one-pot three-component reaction of carbonyl compounds, substituted anilines and trialkyl phosphites. Various α-aminophosphonates were synthesized in good to high yields under solvent-free conditions at room temperature. The catalyst was reused five times without significant loss of its activity.

Keywords

Multifunctional catalyst

One-pot reaction

α-Aminophosphonates

Kabachnik-Fields reaction