Convenient One-pot Access to Pyrano[2,3-d]pyrimidine Derivatives via a CuCl2.2H2O Catalyzed Knoevenagel-Michael Addition Reaction in Water/Ethanol Media

Document Type : Full Paper


1 Sistan & Baluchestan University, Zahedan, IRAN

2 Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674 Zahedan, Iran

3 Faculty of Science, Velayat University, Iranshar, Iran

4 Chemistry department of, The University of Sistan and Baluchestan, P. O. Box 98135-674, Zahedan, Iran


Convenient procedure for the synthesis of corresponding pyrano[2,3-d]pyrimidine derivatives were developed via one-pot three-component reaction of aryl aldehyde derivatives, malononitrile with barbituric acids in the presence of copper (II) chloride dihydrate (CuCl2.2H2O) as highly efficient Lewis acid catalyst. This protocol has advantages such as readily and inexpensive catalyst, high reaction yields, eco-friendly solvent and high atom-economy.