Synthesis of Naphthopyranopyrimidines Using Formic Acid as an Effective Catalyst under Solvent-free Conditions

Document Type : Full Paper

Authors

1 Department of Chemistry, Faculty of Sciences, University of Sistan and Baluchestan, P.O. Box 98135-674, Zahedan, Iran

2 Faculty of Sciences, Velayat University, Iranshahr, Iran

3 Department of Chemistry, Faculty of Sciences, University of Sistan and Baluchestan, Zahedan 98135-674, Iran

Abstract

An environmentally friendly, one-pot, three-component synthesis of 8,10-dimethyl-12-aryl-12H-naphtho[1′,2′:5,6]pyrano[2,3-d]pyrimidine-9,11-diones was achieved via coupling aromatic of aldehydes, β-naphthol and 6-amino-1,3-dimethyl uracil in the presence of formic acid as a catalyst under solvent-free conditions at 90 °C. This method has several advantages, such as efficiency, good yield, short reaction time, cleaner reaction profiles, ease of product isolation, operational simplicity and inexpensive, effective and catalyst.

Keywords

Organic Chemistry Research
Volume 4, Issue 2
June 2018
Pages 124-130

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