One-pot Synthesis of Some Novel 2-[(Z)-1-(Aryl)]-6,7-dihydro-2H-istohiazolo[2,3-a]pyrimidine-3(5H)-one Derivatives

Document Type : Research Paper

Authors

1 Chemistry Department, Arak University, Dr. Beheshti Ave, Arak, Iran

2 Faculty of Chemistry, Tehran North Branch, Islamic Azad University, Tehran, Iran

3 Department of Chemistry, Islamic Azad University-Dezful Branch, Dezful, Iran.

4 Department of Chemistry, Faculty of Science, Arak University, Arak, Iran

Abstract

Reaction of 3,4,5,6-tetrahydro-2-pyrimidinethiol, prepared by cyclocondensation reaction of 1,3-diamino propane 1 and carbon disulfide, with ethyl chloroacetate and substituted aromatic aldehydes in the presence of sodium acetate and acetic acid gave 2-[(Z)-1-(aryl)]-6,7-dihydro-2H-isothiazolo[2,3-a]pyrimidine-3(5H)-one derivatives 3(a-j) in good yields. 1H-NMR spectroscopy, and elemental analysis were used for identification of these compounds.

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