Green Multicomponent Synthesis of Benzodiazepines in the Presence of CuFe2O4 as an Efficient Magnetically Recyclable Nanocatalyst under Solvent-Free Ball-Milling Conditions at Room Temperature

Document Type : Full Paper


Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran 16846-13114, Iran


In this work, an efficient and green procedure for the synthesis of various substituted 1,5-benzodiazepine derivatives via a one-pot three-component catalytic reaction has been described. The reaction was conducted between o-phenylenediamine, dimedone and aldehyde derivatives in the presence of CuFe2O4 nanoparticles as a magnetic heterogeneous nanocatalyst under ball-milling conditions at room temperature. High yields of the products, short reaction times, simplicity of operation, mild reaction conditions, non-toxicity, easy work-up and purification of the products through crystallization method (chromatography-free) and recyclability of the catalyst are added advantages of this work.