Ultrasonic-assisted Synthetic Improvement of Fluorinated Five- and Six-membered Triazolotriazine and Triazinophthalazine Heterocycles

Document Type : Full Paper


Department of Chemistry Vali-e-Asr University of Rafsanjan Rafsanjan Iran


In this investigation a simple synthetic method for the synthesis of trifluoromethyl-1H-benzo[e][1,2,4]triazolo[1,2-a][1,2,4]triazine-1,3(2H)-diones and (trifluoromethyl)benzo [5,6][1,2,4]triazino[1,2-b]phthalazine-8,13-diones has been developed using urazole or phthalazine and aceteimidoyl chloride derivatives at room temperature under ultrasound irradiations. In the comparison to the conventional method the ultrasound irradiation increased the yield and the reactions times decreased considerably.