A practical and green synthesis of 3-substituted indoles is reported via three-component coupling reaction of indoles, aldehydes and N-methylaniline in the presence of the acidic ionic liquid 1-butyl-3-methylimidazolium hydrogen sulfate ([BMIm]HSO4) under ultrasound irradiation at room temperature. The significant features of this procedure are high yields of the products, simple work-up, operational simplicity and non-toxicity of the catalyst. Moreover, [BMIm]HSO4 is successfully reused for four cycles without significant less of activity. Keywords. Indoles, N-methylaniline, Aldehyde, Ionic liquid.
Shirini, F., & Azimi, S. C. (2017). [BMIm]HSO4 as a Green and Highly Efficient Catalyst for One-pot Synthesis of 3-Substituted Indoles under Ultrasound Irradiation. Organic Chemistry Research, 3(2), 176-186. doi: 10.22036/org.chem.2017.96868.1107
MLA
Farhad Shirini; Seyyedeh Cobra Azimi. "[BMIm]HSO4 as a Green and Highly Efficient Catalyst for One-pot Synthesis of 3-Substituted Indoles under Ultrasound Irradiation". Organic Chemistry Research, 3, 2, 2017, 176-186. doi: 10.22036/org.chem.2017.96868.1107
HARVARD
Shirini, F., Azimi, S. C. (2017). '[BMIm]HSO4 as a Green and Highly Efficient Catalyst for One-pot Synthesis of 3-Substituted Indoles under Ultrasound Irradiation', Organic Chemistry Research, 3(2), pp. 176-186. doi: 10.22036/org.chem.2017.96868.1107
VANCOUVER
Shirini, F., Azimi, S. C. [BMIm]HSO4 as a Green and Highly Efficient Catalyst for One-pot Synthesis of 3-Substituted Indoles under Ultrasound Irradiation. Organic Chemistry Research, 2017; 3(2): 176-186. doi: 10.22036/org.chem.2017.96868.1107