Natural Biopolymers is an Efficient Catalyst for the Synthesis of 1,3,5-Trisubstituted Pyrazoles

Document Type : Full Paper


Department of Chemistry, Faculty of Science, University of Jiroft, Jiroft, P. O. Box 8767161167, Iran


Cellulose sulfuric acid is an efficient metal-free catalyst for the synthesis of 1,3,5-trisubstituted pyrazoles via the condensation of 1,3-diketones and hydrazines. The reaction was carried out in Solvent-free condition at room temperature and the products were isolated in good to excellent yields. Mild reaction conditions, as well as ease of operation and workup are some advantages of the proposed protocol.