Layered Double Hydroxides (LDHs): An Efficient Catalyst System for the Synthesis of Chiral Aminonitriles

Document Type : Full Paper


1 Razi Vaccine and Serum Research Institute, Agricultural Research and Extension Organization (AREEO), Karaj, Iran

2 Department of Chemistry, Tehran East branch, Islamic Azad University, Tehran, Iran

3 Department of Chemistry, Iran University of Science and Technology, Tehran, Iran


Strecker reaction is one of the simplest multicomponent reactions. It used for synthesis of chiral α-amino nitriles. This reaction was carried out in the presence of catalytic amount of layered double hydroxides (LDHs). In this study, simple and practical method for the synthesis of this class of catalysts is provided. The results shown that LDH is the good heterogen catalyst for synthesis of chiral α-amino nitriles.