Advanced Methods for the Synthesis of Nitro Compounds

Document Type : MiniReviews Article


1 Department of Organic Chemistry, Faculty of Chemistry and Petroleum Sciences, Bu-Ali Sina University, Hamedan, Iran

2 Department of Chemistry, Faculty of Science, University of Qom, Qom, 3716146611, Iran



The chemistry of nitration reactions is a very powerful tool for the synthesis of pharmaceutical molecules and biological compounds. Carbon-nitrogen (C-N) bond formation is one of the most important reactions in organic synthesis, which plays a key role in the synthesis of biologically active and targeted molecules. Nitro compounds are very useful and have shown their importance in various medical, environmental and military fields for the synthesis of energetic and explosive compounds. Nitration reactions are conducted through various methods and employing diverse reagents, illustrating the multiplicity of their synthesis pathways. Diversifying the chemistry of nitro compounds offers a promising avenue for generating novel targeted molecules, showcasing the potential of these substances and the method itself. The objective herein is to highlight a selection of reagents and pathways for synthesizing nitro compounds that have garnered significant interest from research groups in recent years.


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