Choline Chloride-urea as a Solvent/catalyst for the Synthesis of 2-Aminoimidazopyridines via Strecker Reaction

Document Type : Full Paper

Authors

1 Department of Chemistry, Faculty of Science, Babol Noshirvani University of Technology, Shariati Ave., Babol 47148-71167, Iran

2 Graduate student from School of Chemistry, Shahrood University of Technology, Shahrood 36199-95161, Iran

10.22036/org.chem.2024.435241.1316

Abstract

The three-component Strecker reaction between 2-aminopyridine, aldehyde, and KCN in choline chloride-urea deep eutectic solvent (DES) was used for the synthesis of 2-aminoimidazopyridines. This reaction was carried out in simple conditions, and the reaction yields were very favorable. The use of the choline chloride-urea as an environmentally friendly solvent/catalyst is the main advantage of the presented synthesis method.

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Choline Chloride-urea as a Solvent/catalyst for the Synthesis of 2-Aminoimidazopyridines via Strecker Reaction

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Organic Chemistry Research
Volume 8, Issue 2
December 2022
Pages 95-98

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