Synthesis of Novel 1,2,3-Triazoles-linked Indoles Through Copper(I)-catalyzed Click Reactions

Document Type : Full Paper


Faculty of Chemistry, Shahrood University of Technology, Shahrood 3619995161, Iran



A series of novel 1,2,3-triazoles-linked indole derivatives were prepared by the reaction of 2-aryl-1-(prop-2-ynyl)-1H-indole-3-carbaldehydes with aryl azides via copper-catalyzed azide-alkyne cycloaddition reactions in the presence of sodium ascorbate, as a reducing agent. The effects of catalysts, solvents, and reaction temperature were investigated. Under the optimal condition, 1,2,3-triazoles linked-indoles were obtained in 63–92% yields.