Document Type : Full Paper
Department of Chemistry, Faculty of Sciences, University of Guilan, P.O. Box 41335-1914, Rasht, Iran
Department of Chemistry, Faculty of Sciences, University of Guilan, P. O. Box: 41335-1914, Rasht, Iran
A novel and practical method for the synthesis of pyridopyrimidine-indole hybrids, using a three-component reaction of thiouracil or 6-amino-N,N-dimethyluracil, various aryl aldehydes and 3-cyanoacetyl indole in the presence of a green heterogeneous nano-catalyst γ-Fe2O3@HAp@PBABMD@Cu was developed. This protocol furnished the desired products in high yields (82-95%) and lower reaction times (18-40 min).