Synthesis of some 4H-Pyran Derivatives Using Bio-synthesized ZnO Nanoparticles and the Evaluation of their Biological Activities

Document Type : Full Paper


1 Department of Chemistry, Faculty of Science, Arak University, Arak 38156-88349, Iran

2 Department of Chemistry, Payam Noor University, Golpayegan, Iran

3 Department of Chemistry, Dezful Branch, Islamic Azad University, Dezful, Iran

4 Department of Biology, Faculty of Science, Arak University, Arak 38156-88349, Iran



ZnO Nanoparticles were simply synthesized by green biosynthesis method using ficus carica leaf extract. The structure of these nanoparticles was assigned using Fourier transform infrared spectroscopy (IR), Field emission-scanning electron microscopy (FE-SEM) and X‐ray powder diffraction (XRD). The catalytic activity of these nanoparticles was studied for synthesis of 4H-pyrans. A series of 4H-pyrans 3(a-l) were synthesized in good to high yields by reaction of corresponding α,α′-bis(substituted benzylidene) cycloalkanones and malononitrile in the presence of ZnO nanoparticles as a catalyst at 110 ℃. This environmentally friendly method has some advantages such as high efficiency, use of available catalyst, solvent-free reaction conditions and easy operation. The antibacterial activity of synthesized 4H-pyrans was also tested using Staphylococcus aureus and Escherichia coli bacterial strain.