Catalyst-free Preparation of 4H-1,3,4-Oxadiazines in H2O

Document Type : Full Paper


Department of Chemistry, College of Science, Yazd University, P. O. Box: 89195-741, Yazd, Iran



This report provides a description of a novel and efficient procedure for the synthesis of substituted 4H-1,3,4-oxadiazines via reaction of various vinyl cyanides and acetohydrazide in H2O under catalyst-free conditions. The remarkable advantages are the simplicity of the experimental procedures, high yields, and avoidance of organic solvents. Products were characterized by melting point, IR, 1H- and 13C-NMR spectra, and elemental analysis. The desired products were obtained in >85% yields.