Synthesis of 6-Amino-4-aryl-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles in the Presence of Reusable Catalyst "Celloluse"

Document Type : Full Paper


1 Department of Chemistry, University of Sistan and Baluchestan, P.O. Box 98135 – 674, Zahedan, Iran

2 Department of Chemistry, Faculty of Sciences, University of Sistan and Baluchestan, Zahedan 98135-674, Iran


     Cellulose was applied as a reusable and green catalyst for the facile four-component synthesis of 6-amino-4-aryl-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile derivatives using hydrazine monohydrate, ethyl acetoacetate, malononitrile and aryl aldehydes, under solvent-free and thermal conditions. The use of non-toxic and inexpensive catalyst, short reaction time, clean work-up and good yields of the products are advantages of this method.