A One-Pot Synthesis of Some Novel Ethyl 2-((1H-Benzo[d]imidazol-2-ylamino)(Aryl)methylthio)acetates by Nano-CuY Zeolite as an Efficient and Eco-Friendly Nanocatalyst

Document Type : Full Paper


Department of chemistry, Payame Noor University


A one-pot multicomponent reaction of aryl aldehydes, 2-amino benzimidazole and ethyl 2-mercaptoacetate is described as an efficient and environmentally method for the synthesis of  some  novel  ethyl  2-((1H-benzo[d]imidazol-2-ylamino)(Aryl)methylthio)  acetates  in  the presence of nano-Copper Y Zeolite (NCZ) as a catalyst in ethanol at room temperature. After optimizing of reaction conditions for this reaction, the amount of catalyst obtained was 10W%. The yield of reactions was in the range of 75-89%. The synthesized compounds 4a-j were characterized using IR, 1H NMR, 13C NMR spectroscopy and Elemental Analysis.  The  present  procedure  offers  several advantages,  such  as  use  of  available,  safety  and reusable of  the  catalyst,  high  yields,  short reaction  times,  easy  and  quick  isolation  of  the  product. This  method  may  provide a developed groundwork  for  the  synthesis  of  new  commercial  fungicide  Benomyl  and  Carbendazim derivatives. Also, this procedure may be used as a synthetic pathway for preparation of new sulfur-bearing peptide derivatives based on 2-amino benzimidazole core under mild conditions.