Ultrasound-Promoted Synthesis of Aryl Amides from Isocyanides and Carboxylic Acids under Ambient Conditions

Document Type : Full Paper


1 Department of Chemistry, University of Zanjan, P O Box 45195-313, Zanjan, Iran

2 Young Researchers and Elite Club, Zanjan Branch, Islamic Azad University, Zanjan, Iran

3 School of Mechanical Engineering, Yeungnam University, Gyongsan 712-749, Korea


The synthesis of aryl amides via the reactions of carboxylic acids and isocyanides in methanol was carried out in 78-95% yields under ultrasound irradiation. The method has wide applicability, and the protocol is mild, fast and efficient compared to the existing methods based on silent conditions.