TY - JOUR ID - 141377 TI - Catalyst-free Preparation of 4H-1,3,4-Oxadiazines in H2O JO - Organic Chemistry Research JA - ORG.CHEM LA - en SN - AU - Mozafari Vanani, Sedighe AU - Amrollahi, Mohammad Ali AD - Department of Chemistry, College of Science, Yazd University, P. O. Box: 89195-741, Yazd, Iran Y1 - 2021 PY - 2021 VL - 7 IS - 1 SP - 54 EP - 60 KW - Acetohydrazide KW - Catalyst-free KW - Cyclization KW - Oxadiazines KW - Vinyl cyanides KW - Aqueous DO - 10.22036/org.chem.2021.255031.1257 N2 - This report provides a description of a novel and efficient procedure for the synthesis of substituted 4H-1,3,4-oxadiazines via reaction of various vinyl cyanides and acetohydrazide in H2O under catalyst-free conditions. The remarkable advantages are the simplicity of the experimental procedures, high yields, and avoidance of organic solvents. Products were characterized by melting point, IR, 1H- and 13C-NMR spectra, and elemental analysis. The desired products were obtained in >85% yields. UR - https://www.orgchemres.org/article_141377.html L1 - https://www.orgchemres.org/article_141377_93da2be194e0278c630af50b13816a87.pdf ER -