TY - JOUR ID - 10660 TI - Phosphotungstic Acidcatalyzed Strecker Three-Component Reaction of Amino Acids, Aldehydes, and Trimethylsilyl Cyanide JO - Organic Chemistry Research JA - ORG.CHEM LA - en SN - AU - Balalaie, Saeed AU - Tahoori, Fatemeh AU - Khatibi, Negin AD - Department of Chemistry, K.N. Toosi University of Technology, P.O. Box: 15875-4416, Tehran, Iran Fax: +98-21-2285 3650 , Balalaie@kntu.ac.ir&Balalaie@yahoo.com AD - Department of Chemistry, K.N. Toosi University of Technology, P.O. Box: 15875-4416, Tehran, Iran Y1 - 2015 PY - 2015 VL - 1 IS - 1 SP - 18 EP - 26 KW - Strecker reaction KW - Protected α-amino acid KW - Heteropoly acid KW - Phosphotungstic acid KW - Trimethylsilyl cyanide KW - Environmentally friendly catalyst KW - Diastereoselectivity DO - 10.22036/org.chem..2015.10660 N2 - A simple and efficient one-pot, three-component Strecker reaction of protected amino acids, aromatic aldehydes, and trimethylsilyl cyanide has been developed for the synthesis of chiral α-amino nitriles. The reaction was carried out in the presence of catalytic amount of phosphotungstic acid (H3[P(W3O10)4]) as an environmentally friendly catalyst. UR - https://www.orgchemres.org/article_10660.html L1 - https://www.orgchemres.org/article_10660_854951887dad5c0061a5fd8c78c7fcb2.pdf ER -