%0 Journal Article %T One-pot Four-component Reaction between Arylamines, Arylglyoxals, Cyclohexyl Isocyanide, and Acetylene Diesters: An Efficient Synthesis of 2H-iminopyran Derivatives %J Organic Chemistry Research %I Iranian Chemical Society %Z 2383-242X %A Anary-Abbasinejad, Mohammad %A Jaafari, Maryam %A Talebizadeh, Mahdiyeh %D 2019 %\ 12/01/2019 %V 5 %N 2 %P 139-144 %! One-pot Four-component Reaction between Arylamines, Arylglyoxals, Cyclohexyl Isocyanide, and Acetylene Diesters: An Efficient Synthesis of 2H-iminopyran Derivatives %K α-Iminoketones %K Isocyanide %K Iminopyrans %K Four-component reaction %K Arylglyoxals %R 10.22036/org.chem.2018.135033.1159 %X A facile synthesis of highly functionalized 2H-iminopyran derivatives by the multi-component reaction of cyclohexyl isocyanide, dialkyl acetylenedicarboxylates, arylglyoxals and arylamines is described. The zwitterionic intermediate produced by addition of cyclohexyl isocyanide to electron-deficient acetylene diesters was trapped by the electrophilic imine moiety of α-iminoketones, derived from arylglyoxals and arylamines, to afford an inner salt intermediate which converted to 2H-iminopyran derivatives by an intramolecular cyclization. %U https://www.orgchemres.org/article_82413_8a53b4049d01c25cde499f8d1f9c597d.pdf