%0 Journal Article %T Synthesis and Biological Evaluation of Novel Quinoline Derivatives as Antibacterial and Antifungal Agents %J Organic Chemistry Research %I Iranian Chemical Society %Z 2383-242X %A Shiri, Morteza %A Nejatinejhad-Arani, Atefeh %A Faghihi, Zeynab %A Shintre, Suhas A. %A Koorbanally, Neil A. %D 2016 %\ 09/01/2016 %V 2 %N 2 %P 113-119 %! Synthesis and Biological Evaluation of Novel Quinoline Derivatives as Antibacterial and Antifungal Agents %K Multicomponent condensation %K Quinolines %K Diamides %K antibacterial %K Antifungal %R 10.22036/org.chem..2016.14694 %X Vilsmeier Several diamide derivatives containing 2-chloroquinoline scaffolds were synthesized via Ugi reaction of 2-chloroquinoline-3-carboxaldehydes, amines, carboxylic acids and isocyanides. The diversity of these quinolinyl Ugi-adducts was increased by using 2-chloroquinoline-3-carboxylic acids as a source of acid. Among them, compounds 2d, 2n, 2p, 4a, 4c and 4e displayed moderate to good antibacterial and antifungal activity. %U https://www.orgchemres.org/article_14694_0fd624655cb72999f2f6451e54172632.pdf