Four-component Cascade Reaction was Programmed and Catalyzed by B(OH)3.H2O as an Efficient and Green Catalytic System

Document Type : Full Paper

Authors

1 Department of Chemistry, University of Sayyed Jamaleddin Asadabadi, Asadabad 6541835583, Iran

2 Sayyed Jamaleddin Asadabadi University, Asadabad, 6541835583, I. R. Iran.

3 Khajeh Nasir Toosi University, Tehran, Iran

4 Sayyed Jamaleddin Asadabadi University, Asadabad, 6541835583, I. R. Iran

Abstract

An aqueous solution of boric acid, as an efficient and green catalytic system, was efficiently utilized four-component cascade reaction of aryl aldehydes, dimedone, β-ketoesters and ammonium acetate to give hexahydroquinolines. By the reaction of boric acid with water, H+ was generated and efficiently catalyzed the reaction under mild and green condition. Also, optimization of the reaction condition was investigated using the response surface method {Central Composite Design (CCD)}.

Keywords

Organic Chemistry Research
Volume 5, Issue 2
December 2019
Pages 159-166

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