Synthesis of Quinazolinone Derivatives through Multicomponent/Click Reactions

Document Type : Full Paper

Authors

1 Alzahra University

2 Chemistry, Alzahra University

3 Chemistry, Alzahra university

4 University of Tehran

Abstract

Quinazolinones were synthesized through the one-pot three-component reaction of aromatic aldehydes, isatoic anhydride, and urea under solvent-free conditions using sulfonic acid functionalized mesoporous silica (SBA-Pr-SO3H). The propargyl ether containing 2,3-dihydroquinazolin-4(1H)-ones were reacted with sodium azide in the presence of CuI to gain the new triazole-quinazolinone products.

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