Chemoselective N-tert-butoxycarbonylation and N-formylation of Amines by B(OSO3H)3/SiO2 as an Efficient Heterogeneous and Recyclable Catalyst

Hamadi, Hosein; Gholami, Maryam

doi:10.22036/org.chem.2018.130876.1142

Chemoselective N-tert-butoxycarbonylation and N-formylation of Amines by B(OSO3H)3/SiO2 as an Efficient Heterogeneous and Recyclable Catalyst

Document Type : Full Paper

Authors

Hosein Hamadi ¹

Maryam Gholami ²

¹ Shahid Chamran University of Ahvaz

² Chemistry Department, Faculty of Sciences, Shahid Chamran University of Ahvaz

10.22036/org.chem.2018.130876.1142

Abstract

A simple, efficient, and cost-effective procedure for the N-tert-butoxycarbonylation and N-formylation of amines (primary, secondary) respectively, with di-tert-butyl dicarbonate and 85% aqueous formic acid under solvent-free condition using B(OSO3H)3/SiO2 (SBSA) as a heterogeneous and recyclable catalyst has been developed. We demonstrated that the resulting catalyst is applicable to various aromatic and aliphatic amines giving excellent yields of the desired products in short reaction time (

Keywords

Protection

Boc

Formylation

Catalyst

B(OSO3H)3