Document Type: Research Paper
Sistan &amp; Baluchestan University, Zahedan, IRAN
Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674 Zahedan, Iran
Faculty of Science, Velayat University, Iranshar, Iran
Chemistry department of, The University of Sistan and Baluchestan, P. O. Box 98135-674, Zahedan, Iran
Convenient procedure for the synthesis of corresponding pyrano[2,3-d]pyrimidine derivatives were developed via one-pot three-component reaction of aryl aldehyde derivatives, malononitrile with barbituric acids in the presence of copper (II) chloride dihydrate (CuCl2.2H2O) as highly efficient Lewis acid catalyst. This protocol has advantages such as readily and inexpensive catalyst, high reaction yields, eco-friendly solvent and high atom-economy.