Fe(HSO4)3-Catalyzed Direct Conversion of Aldehydes into Nitriles Using Hydroxylamine Hydrochloride

Taheri, Hassan; Shiri, Ali; Eshghi, Hossein; Sheikhi-Mohammareh, Seddigheh

doi:10.22036/org.chem.2017.75197.1084

Fe(HSO4)3-Catalyzed Direct Conversion of Aldehydes into Nitriles Using Hydroxylamine Hydrochloride

Document Type : Full Paper

Authors

Hassan Taheri ¹

Ali Shiri ²

Hossein Eshghi ³

Seddigheh Sheikhi-Mohammareh ¹

¹ Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, 91775-1436 Mashhad, Iran.

² Ferdowsi University of Mashhad

³ Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, Mashhad

10.22036/org.chem.2017.75197.1084

Abstract

Due to the importance and various applications of nitriles especially in medicinal productions, a new method for conversion of aldehydes to nitriles has been presented. Several nitrile-containing aromatic compounds were synthesized through the treatment of various aldehydes and hydroxylamine hydrochloride as nucleophile in the presence of ferric hydrogen sulfate as a heterogeneous, efficient, and recyclable catalyst in DMF in good to excellent yields.

Keywords

hydroxylamine hydrochloride

Ferric hydrogen sulfate

Nitriles

Aldehydes