Document Type : Research Paper
Department of chemistry, Payame Noor University
A one-pot multicomponent reaction of aryl aldehydes, 2-amino benzimidazole and ethyl 2-mercaptoacetate is described as an efficient and environmentally method for the synthesis of some novel ethyl 2-((1H-benzo[d]imidazol-2-ylamino)(Aryl)methylthio) acetates in the presence of nano-Copper Y Zeolite (NCZ) as a catalyst in ethanol at room temperature. After optimizing of reaction conditions for this reaction, the amount of catalyst obtained was 10W%. The yield of reactions was in the range of 75-89%. The synthesized compounds 4a-j were characterized using IR, 1H NMR, 13C NMR spectroscopy and Elemental Analysis. The present procedure offers several advantages, such as use of available, safety and reusable of the catalyst, high yields, short reaction times, easy and quick isolation of the product. This method may provide a developed groundwork for the synthesis of new commercial fungicide Benomyl and Carbendazim derivatives. Also, this procedure may be used as a synthetic pathway for preparation of new sulfur-bearing peptide derivatives based on 2-amino benzimidazole core under mild conditions.