Phosphotungstic Acidcatalyzed Strecker Three-Component Reaction of Amino Acids, Aldehydes, and Trimethylsilyl Cyanide

Document Type: Research Paper

Authors

1 Department of Chemistry, K.N. Toosi University of Technology, P.O. Box: 15875-4416, Tehran, Iran Fax: +98-21-2285 3650 , Balalaie@kntu.ac.ir&Balalaie@yahoo.com

2 Department of Chemistry, K.N. Toosi University of Technology, P.O. Box: 15875-4416, Tehran, Iran

Abstract

A simple and efficient one-pot, three-component Strecker reaction of protected amino acids, aromatic aldehydes, and trimethylsilyl cyanide has been developed for the synthesis of chiral α-amino nitriles. The reaction was carried out in the presence of catalytic amount of phosphotungstic acid (H3[P(W3O10)4]) as an environmentally friendly catalyst.

Keywords