TY - JOUR ID - 65270 TI - Convenient One-pot Access to Pyrano[2,3-d]pyrimidine Derivatives via a CuCl2.2H2O Catalyzed Knoevenagel-Michael Addition Reaction in Water/Ethanol Media JO - Organic Chemistry Research JA - ORG.CHEM LA - en SN - AU - Maghsoodlu,, M AU - Mohamadpour, Farzaneh AU - Lashkari, Mojtaba AU - Hazeri, Nourallah AD - Sistan & Baluchestan University, Zahedan, IRAN AD - Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674 Zahedan, Iran AD - Faculty of Science, Velayat University, Iranshar, Iran AD - Chemistry department of, The University of Sistan and Baluchestan, P. O. Box 98135-674, Zahedan, Iran Y1 - 2018 PY - 2018 VL - 4 IS - 2 SP - 140 EP - 146 KW - Sustainable procedure KW - Copper(II) chloride dihydrate (CuCl2.2H2O) KW - Water/ethanol media KW - Pyrano[2 KW - 3-d]pyrimidine derivatives KW - One-pot reaction DO - 10.22036/org.chem.2018.97056.1109 N2 - Convenient procedure for the synthesis of corresponding pyrano[2,3-d]pyrimidine derivatives were developed via one-pot three-component reaction of aryl aldehyde derivatives, malononitrile with barbituric acids in the presence of copper (II) chloride dihydrate (CuCl2.2H2O) as highly efficient Lewis acid catalyst. This protocol has advantages such as readily and inexpensive catalyst, high reaction yields, eco-friendly solvent and high atom-economy. UR - https://www.orgchemres.org/article_65270.html L1 - https://www.orgchemres.org/article_65270_8c509ecdc68d718505790a0926ce7034.pdf ER -