%0 Journal Article %T Synthesis of New Benzothiazole Derivatives and Evaluation of Cytotoxicity of N-(6-Substitued-1,3-benzothiazol-2-yl)-4-phenyl-1,3-thiazol-2(3H)-imine Compounds %J Organic Chemistry Research %I Iranian Chemical Society %Z 2383-242X %A Eshghi, Hossein %A Eshkil, Fatemeh %A SHokooh Saljooghi, Amir %A Bakavoli, Mehdi %D 2019 %\ 09/01/2019 %V 5 %N 1 %P 87-94 %! Synthesis of New Benzothiazole Derivatives and Evaluation of Cytotoxicity of N-(6-Substitued-1,3-benzothiazol-2-yl)-4-phenyl-1,3-thiazol-2(3H)-imine Compounds %K Unsymmetrical thioureas %K MTT-assay %K Flow Cytometry %K TUNEL assay %K 1-(1 %K 3-benzothiazol-2-yl)thiourea %K 3-(benzo[d]thiazol-2- yl)-2-thioxo-2 %K 3-dihydroquinazolin-4(1H)-one %R 10.22036/org.chem.2018.133272.1148 %X Cyclization of unsymmetrical thioureas affords N-(6-substitued-1,3-benzothiazol-2-yl)-4-phenyl-1,3-thiazol-2(3H)-imine compounds by the reaction of 1-(1,3-benzothiazol-2-yl)thiourea derivatives and 2-bromoacetophenone in the presence of Et3N. Also, methyl-1,3-benzothiazol-2-yl carbamodithioate derivatives with methyl anthranilate were reacted and 3-(benzo[d]thiazol-2-yl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one derivatives as new compounds are synthesized. In the following, synthesized compounds (2a- 2d) were evaluated for anti-tumor activity against MCF-7, MAD-MD-231, HT-29, HeLa, Neuro-2a, K-562 and L-929 cell lines and the results obtained from MTT-assay revealed the best cytotoxicity for 2b compound containing a phenolic segment in their buildings. On the other hand, apoptosis assay for this compound was also carried out by flow cytometry supporting the other results. %U https://www.orgchemres.org/article_79186_b8ba449dbb668c3473cd1391647e3844.pdf