%0 Journal Article %T An Efficient Synthesis of 3,4-Dihydropyrimidin-2-(1H)-one Derivatives Promoted by Antimony Trichloride under Thermal and Solvent-free Conditions %J Organic Chemistry Research %I Iranian Chemical Society %Z 2383-242X %A Mohamadpour, Farzaneh %A Maghsoodlu, Malek Taher %A Heydari, Reza %A Lashkari, Mojtaba %D 2016 %\ 09/01/2016 %V 2 %N 2 %P 127-133 %! An Efficient Synthesis of 3,4-Dihydropyrimidin-2-(1H)-one Derivatives Promoted by Antimony Trichloride under Thermal and Solvent-free Conditions %K Antimony trichloride (SbCl3) %K 3 %K 4-Dihydropyrimidinone %K Multi-component synthesis %K Biginelli reaction %R 10.22036/org.chem..2016.14892 %X An efficient and simple one-pot approach for the synthesis of 3,4-dihydropyrimidin-2-(1H)-one derivatives using antimony trichloride (SbCl3) as a mild catalyst by means of three-component Biginelli reaction between β-keto esters, aldehyde derivatives and urea/thiourea under thermal and solvent-free conditions with excellent yields and short reaction times is reported. This methodology offers several merits such as excellent yields, short reaction times, efficient, eco-friendly, solvent-free conditions, materials available, and simple operational procedure with no column chromatographic separation. The products are characterized by melting points and 1H NMR spectroscopy. %U https://www.orgchemres.org/article_14892_8e4c06b2464d3c3f778157e5ac178677.pdf