%0 Journal Article %T Phosphotungstic Acidcatalyzed Strecker Three-Component Reaction of Amino Acids, Aldehydes, and Trimethylsilyl Cyanide %J Organic Chemistry Research %I Iranian Chemical Society %Z 2383-242X %A Balalaie, Saeed %A Tahoori, Fatemeh %A Khatibi, Negin %D 2015 %\ 09/01/2015 %V 1 %N 1 %P 18-26 %! Phosphotungstic Acidcatalyzed Strecker Three-Component Reaction of Amino Acids, Aldehydes, and Trimethylsilyl Cyanide %K Strecker reaction %K Protected α-amino acid %K Heteropoly acid %K Phosphotungstic acid %K Trimethylsilyl cyanide %K Environmentally friendly catalyst %K Diastereoselectivity %R 10.22036/org.chem..2015.10660 %X A simple and efficient one-pot, three-component Strecker reaction of protected amino acids, aromatic aldehydes, and trimethylsilyl cyanide has been developed for the synthesis of chiral α-amino nitriles. The reaction was carried out in the presence of catalytic amount of phosphotungstic acid (H3[P(W3O10)4]) as an environmentally friendly catalyst. %U https://www.orgchemres.org/article_10660_854951887dad5c0061a5fd8c78c7fcb2.pdf