@article { author = {Karimi, Ali Reza and Tajabadi, Zeinab and Khodadadi, Azam and Abdi, Fereshteh}, title = {3-(Propylcarbamoyl)acrylic Acid Functionalized Magnetic Nanoparticles Grafted to Poly (N-isopropylacrylamide-co-Acrylic Acid) Hydrogel: LCST and Drug Release}, journal = {Organic Chemistry Research}, volume = {5}, number = {1}, pages = {51-63}, year = {2019}, publisher = {Iranian Chemical Society}, issn = {2383-242X}, eissn = {2383-242X}, doi = {10.22036/org.chem.2018.134334.1155}, abstract = {In this research, to overcome the low mechanical properties of hydrogels based on Poly N-isopropylacrylamide (PNIPAAm) and improve their stimuli responsive behavior and lower critical solution temperature LCST, a new kind of hybrid magnetic nanoparticles was designed and prepared and then grafted to (PNIPAAm-co-AAc) hydrogel through in situ dispersion copolymerization route. 3-(propylcarbamoyl)acrylic acid functionalized silica-coated magnetic nanoparticles (PC-AAc/MNPs) was prepared and used as a template for in situ dispersion copolymerization of the poly N-isopropylacrylamide (PNIPAAm) and acrylic acid (AAc) in the presence of methylene-bis-acrylamide as a cross-linking agent via free radical cross-linking polymerization. Also, controlled drug release behavior of metronidazole was investigated with prepared nanocomposite hydrogels. The vibrating sample magnetometer (VSM) illustrated superparamagnetic behavior for (PC-AAc/MNPs) and nanoparticles grafted hydrogel. Scanning electron microscopy (SEM) image of functionalized magnetic nanoparticles showed that they are spherical in shape and have the spherical structure with a diameter of about 15-30 nm. Moreover, the lower critical solution temperature (LCST) of the (PC-AAc/MNPs-g-PNIPAAm-co-AAc) hydrogel, as well as the onset temperatures, measured by the cloud point (CP) method at ~ 42 C. Combined magnetic properties and thermosensitive behavior of (PNIPAAm-co-AAc) grafted magnetic nanoparticles could be utilized in controlled drug-targeting delivery. Hence, metronidazole as a model drug loaded on the magnetic hydrogel nanocomposite and the amount of drug release was measured by UV-Vis spectroscopy.}, keywords = {Magnetic polymer,hydrogels,Nanocomposites,Drug delivery systems,LCST}, url = {https://www.orgchemres.org/article_76914.html}, eprint = {https://www.orgchemres.org/article_76914_6c513ee3fa3e4326e3ac2e27d3656fb0.pdf} }