@article { author = {Mozafari Vanani, Sedighe and Amrollahi, Mohammad Ali}, title = {Catalyst-free Preparation of 4H-1,3,4-Oxadiazines in H2O}, journal = {Organic Chemistry Research}, volume = {7}, number = {1}, pages = {54-60}, year = {2021}, publisher = {Iranian Chemical Society}, issn = {2383-242X}, eissn = {2383-242X}, doi = {10.22036/org.chem.2021.255031.1257}, abstract = {This report provides a description of a novel and efficient procedure for the synthesis of substituted 4H-1,3,4-oxadiazines via reaction of various vinyl cyanides and acetohydrazide in H2O under catalyst-free conditions. The remarkable advantages are the simplicity of the experimental procedures, high yields, and avoidance of organic solvents. Products were characterized by melting point, IR, 1H- and 13C-NMR spectra, and elemental analysis. The desired products were obtained in >85% yields.}, keywords = {Acetohydrazide,Catalyst-free,Cyclization,Oxadiazines,Vinyl cyanides,Aqueous}, url = {https://www.orgchemres.org/article_141377.html}, eprint = {https://www.orgchemres.org/article_141377_93da2be194e0278c630af50b13816a87.pdf} }