One-pot Four-component Reaction between Arylamines, Arylglyoxals, Cyclohexyl Isocyanide, and Acetylene Diesters: An Efficient Synthesis of 2H-iminopyran Derivatives
A facile synthesis of highly functionalized 2H-iminopyran derivatives by the multi-component reaction of cyclohexyl isocyanide, dialkyl acetylenedicarboxylates, arylglyoxals and arylamines is described. The zwitterionic intermediate produced by addition of cyclohexyl isocyanide to electron-deficient acetylene diesters was trapped by the electrophilic imine moiety of α-iminoketones, derived from arylglyoxals and arylamines, to afford an inner salt intermediate which converted to 2H-iminopyran derivatives by an intramolecular cyclization.
Anary-Abbasinejad, M., Jaafari, M., & Talebizadeh, M. (2019). One-pot Four-component Reaction between Arylamines, Arylglyoxals, Cyclohexyl Isocyanide, and Acetylene Diesters: An Efficient Synthesis of 2H-iminopyran Derivatives. Organic Chemistry Research, 5(2), 139-144. doi: 10.22036/org.chem.2018.135033.1159
MLA
Mohammad Anary-Abbasinejad; Maryam Jaafari; Mahdiyeh Talebizadeh. "One-pot Four-component Reaction between Arylamines, Arylglyoxals, Cyclohexyl Isocyanide, and Acetylene Diesters: An Efficient Synthesis of 2H-iminopyran Derivatives". Organic Chemistry Research, 5, 2, 2019, 139-144. doi: 10.22036/org.chem.2018.135033.1159
HARVARD
Anary-Abbasinejad, M., Jaafari, M., Talebizadeh, M. (2019). 'One-pot Four-component Reaction between Arylamines, Arylglyoxals, Cyclohexyl Isocyanide, and Acetylene Diesters: An Efficient Synthesis of 2H-iminopyran Derivatives', Organic Chemistry Research, 5(2), pp. 139-144. doi: 10.22036/org.chem.2018.135033.1159
VANCOUVER
Anary-Abbasinejad, M., Jaafari, M., Talebizadeh, M. One-pot Four-component Reaction between Arylamines, Arylglyoxals, Cyclohexyl Isocyanide, and Acetylene Diesters: An Efficient Synthesis of 2H-iminopyran Derivatives. Organic Chemistry Research, 2019; 5(2): 139-144. doi: 10.22036/org.chem.2018.135033.1159