An efficient and simple one-pot approach for the synthesis of 3,4-dihydropyrimidin-2-(1H)-one derivatives using antimony trichloride (SbCl3) as a mild catalyst by means of three-component Biginelli reaction between β-keto esters, aldehyde derivatives and urea/thiourea under thermal and solvent-free conditions with excellent yields and short reaction times is reported. This methodology offers several merits such as excellent yields, short reaction times, efficient, eco-friendly, solvent-free conditions, materials available, and simple operational procedure with no column chromatographic separation. The products are characterized by melting points and 1H NMR spectroscopy.
Mohamadpour, F., Maghsoodlu, M. T., Heydari, R., & Lashkari, M. (2016). An Efficient Synthesis of 3,4-Dihydropyrimidin-2-(1H)-one Derivatives Promoted by Antimony Trichloride under Thermal and Solvent-free Conditions. Organic Chemistry Research, 2(2), 127-133. doi: 10.22036/org.chem..2016.14892
MLA
Farzaneh Mohamadpour; Malek Taher Maghsoodlu; Reza Heydari; Mojtaba Lashkari. "An Efficient Synthesis of 3,4-Dihydropyrimidin-2-(1H)-one Derivatives Promoted by Antimony Trichloride under Thermal and Solvent-free Conditions". Organic Chemistry Research, 2, 2, 2016, 127-133. doi: 10.22036/org.chem..2016.14892
HARVARD
Mohamadpour, F., Maghsoodlu, M. T., Heydari, R., Lashkari, M. (2016). 'An Efficient Synthesis of 3,4-Dihydropyrimidin-2-(1H)-one Derivatives Promoted by Antimony Trichloride under Thermal and Solvent-free Conditions', Organic Chemistry Research, 2(2), pp. 127-133. doi: 10.22036/org.chem..2016.14892
VANCOUVER
Mohamadpour, F., Maghsoodlu, M. T., Heydari, R., Lashkari, M. An Efficient Synthesis of 3,4-Dihydropyrimidin-2-(1H)-one Derivatives Promoted by Antimony Trichloride under Thermal and Solvent-free Conditions. Organic Chemistry Research, 2016; 2(2): 127-133. doi: 10.22036/org.chem..2016.14892